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Water → Methyl 3-(p-Cyanophenyl)-2-(p-cyanobenzoyl)propionate

HRID 569499
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HRID 569499 반응식
[C:1]([C:3]1[CH:15]=[CH:14][C:6]([C:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[O:8])=[CH:5][CH:4]=1)#[N:2].[C:16]([C:18]1[CH:25]=[CH:24][C:21]([CH2:22]Br)=[CH:20][CH:19]=1)#[N:17].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C.C(OCC)(=O)C>[C:16]([C:18]1[CH:25]=[CH:24][C:21]([CH2:22][CH:9]([C:7](=[O:8])[C:6]2[CH:14]=[CH:15][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[C:10]([O:12][CH3:13])=[O:11])=[CH:20][CH:19]=1)#[N:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 869964-(Bromomethyl)benzonitrileHCID 2757970Methyl 3-(4-cyanophenyl)-3-oxopropanoate

생성물 1

HCID 13533626Methyl 3-(p-Cyanophenyl)-2-(p-cyanobenzoyl)propionate

시약·촉매·용매 2

HCID 6228Dimethylformamide용매
HCID 8857Ethyl Acetate용매

실험 절차

Methyl p-cyanobenzoylacetate 17.77 g, 0.087 mole) and p-cyanobenzyl bromide (17.16 g, 0.087 mole) were combined in 525 ml DMF under N2 . K2CO3 (12.1 g, 0.087 mole) was added, the slurry stirred 1.5 hours and finally poured into a mixture of 2.5 liters H2O and 0.5 liter ethyl acetate. The organic layer was separated, washed with fresh H2O and then brine, stripped to dryness, and the residue slurried in ether to yield title product: 14.83 g (53.6%); m.p. 154°-157°; tlc (4:1 toluene:ethyl acetate) Rf 0.44.

후처리

  1. customThe organic layer was separated
  2. washwashed with fresh H2O

출처 및 근거

ORD 기록
ord-11c5b9a18a334f219dcaa219adea7d7c
출처 데이터셋
uspto-grants-1988_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04732907

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