Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-6-(1-piperazinyl)pyrazine → 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide, dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-6-(1-piperazinyl)pyrazine | HCID 107992 | — |
| 반응물 | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| 반응물 | 3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3-(2H)-one 1,1-dioxide | HCID 12477038 | — |
| 생성물 | 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide, dihydrochloride | HCID 88521857 | — |
반응 단계
The title compound is prepared using the procedure of Example 1 using 3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3-(2H)-one 1,1-dioxide instead of 3a,4,7,7a-tetrahydro-4,7-methano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide and 1-(6-chloro-2-pyrazinyl)piperazine instead of 4-(2-pyrimidinyl)piperazine. The final product is converted to its dihydrochloride salt, mp 158°-160° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04732984 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-4931d279d7594679a4d32efc8e4fd4c1 |
| 출처 메모 | uspto-grants-1988_03 |