Acetone → HCID 13067815, 화합물
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C[O-].[Na+].[SH2:4].Br[CH:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH:7]=O.[CH3:14][C:15]([CH3:17])=O.[NH3:18]>O.CO>[CH3:14][C:15]1([CH3:17])[N:18]=[CH:7][CH:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[S:4]1C[O-].[Na+].[SH2:4].Br[CH:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH:7]=O.[CH3:14][C:15]([CH3:17])=O.[NH3:18]>O.CO>[CH3:14][C:15]1([CH3:17])[N:18]=[CH:7][CH:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[S:4]1The procedure of M. Thiel, F. Asinger, K. Schmiedel, (Liebigs Ann. Chem. 611, 121 (1958)) was employed. To a methanol solution (3 liters) containing sodium methoxide (216.7 g, 4.01 mole) at -10° C. was added hydrogen sulfide (~1 lb) until the solution was saturated. To this solution was added dropwise over a 2 hour period 2-bromoheptaldehyde (775 g, 4.01 mol). The temperature of the reaction was maintained at about -10° C. after the addition, acetone (734 g, 12.6 mole) was added over a 10 minute period and the solution was stirred for an additional 20 minutes at about -10° C. at which time ammonia was added over a period of 1.5 hours. The solution was then poured into water (4 liters) and extracted with ether (4×1 liter). The combined etheral extracts were washed with brine (1×1 liter), dried over magnesium suflate and concentrated in vacuo to afford after distillation (70°-80°/1.5 mm) 549 g (74%) of 2,2-dimethyl-5-pentyl-3-thiazoline.
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