Ethyl bromoacetate → 3-Carbethoxymethyl-2-methylthio-7-phenylpyrazolo [1,5-a]-1,3,5-triazine-4-one

HRID 569731노트

반응식

HRID 569731 반응식
[CH3:1][S:2][C:3]1[NH:8][C:7](=[O:9])[N:6]2[N:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:12]=[C:5]2[N:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:25]([O:27][C:28](=[O:31])[CH2:29]Br)[CH3:26]>CN(C)C=O>[C:28]([CH2:29][N:8]1[C:7](=[O:9])[N:6]2[N:10]=[C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:12]=[C:5]2[N:4]=[C:3]1[S:2][CH3:1])([O:27][CH2:25][CH3:26])=[O:31]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 135712889HCID 135712889, 화합물

생성물 1

HCID 140994643-Carbethoxymethyl-2-methylthio-7-phenylpyrazolo [1,5-a]-1,3,5-triazine-4-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 260 mg of 2-methylthio-7-phenylpyrazolo [1,5-a]-1,3,5-triazine-4-one and 140 mg of anhydrous potassium carbonate in 5 ml dry dimethylformamide is stirred at room temperature for 15 min while 0.14 ml ethylbromacetate is added dropwise. The mixture is stirred at room temperature overnight, filtered, and the filter cake washed with dimethylformamide.

후처리

  1. additionis added dropwise
  2. filtrationfiltered
  3. washthe filter cake washed with dimethylformamide

출처 및 근거

ORD 기록
ord-e6c732641fd04d70945b2a1616eeda30
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734414

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