Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisobutylaluminum hydride → (1H-indol-5-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisobutylaluminum hydride | HCID 14487 | — |
| 반응물 | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (1H-indol-5-yl)methanol | HCID 2773458 | — |
반응 단계
96 g (0.548 mole) of 6b are treated analogously to Example 1a in 1,800 ml of ether and 1,391 ml (1.67 moles) of DIBAL (1.2 molar in toluene). After chromatography on silica gel with gradient elution with petroleum ether/ethyl acetate (3:1) and petroleum ether/ethyl acetate (1:1), 39.3 g (49%) of pure product are obtained. C9H9NO (147.2)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04734407 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-bc1b83dde3684cc4aa27d378a6abf204 |
| 출처 메모 | uspto-grants-1988_03 |