2,5-Dimethoxytetrahydrofuran → 6-(4-pyrrol-1-ylphenyl)-4,5-dihydro-2H-pyridazin-3-one

HRID 569771노트

반응식

HRID 569771 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.CO[CH:17]1[CH2:21][CH2:20][CH:19](OC)O1>C(O)(=O)C>[N:1]1([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH2:9][CH2:10][C:11](=[O:14])[NH:12][N:13]=3)=[CH:4][CH:3]=2)[CH:17]=[CH:21][CH:20]=[CH:19]1

참가 물질

4

반응물 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 108670826-(4-aminophenyl)-2H-pyridazin-3-one

생성물 1

HCID 201463216-(4-pyrrol-1-ylphenyl)-4,5-dihydro-2H-pyridazin-3-one수율 25.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 6-(4-aminophenyl)-3(2H)-pyridazinone (3.7 g) and 2,5-dimethoxytetrahydrofuran (2.6 g) in glacial acetic acid (37 ml) is heated under reflux for four hours. The reaction mixture is cooled, filtered and the solid is washed with ethanol, and finally crystallized from methanol to give 1.2 g of the product, 4,5-dihydro-6-[4-(1H)-pyrrol-1-yl)phenyl]-3(2H)-pyridazinone, mp 222°-223° C.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for four hours
  3. temperatureThe reaction mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with ethanol
  6. customfinally crystallized from methanol

출처 및 근거

ORD 기록
ord-0bfde153d865463e8e0d1d61e8c94efe
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734415

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