참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide | HCID 14458987 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide | HCID 14458995 | 98% |
반응 단계
A mixture of 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.4 g) and iron (1.45 g) in acetic acid (66 ml) was stirred at 100° C. for 30 minutes. After cooling, iron was filtered off. The filtrate was evaporated to give a residue, which was made alkaline with aqueous 1N sodium hydroxide and extracted with ethyl acetate. The extract was washed with water and dried. Removal of the solvent gave 2-amino-4-bromo-N-(4-bromo-2-fluorobenzyl)benzamide (3.10 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04734419 |
|---|
| 출처 데이터셋 | uspto-grants-1988_03 |
|---|
| ORD ID | ord-6cdceda0523d43728be68130110121d7 |
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| 출처 메모 | uspto-grants-1988_03 |
|---|
