Acetyl chloride → 5-acetyl-1-benzyl-1,5,6,7-tetrahydro-4H-indazol-4one

HRID 569913노트

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HRID 569913 반응식
C[Si]([N-][Si](C)(C)C)(C)C.[Li+].[CH2:11]([N:18]1[C:26]2[CH2:25][CH2:24][CH2:23][C:22](=[O:27])[C:21]=2[CH:20]=[N:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:28](Cl)(=[O:30])[CH3:29]>O1CCCC1>[C:28]([CH:23]1[CH2:24][CH2:25][C:26]2[N:18]([CH2:11][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:19]=[CH:20][C:21]=2[C:22]1=[O:27])(=[O:30])[CH3:29]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 2733832Lithium HexamethyldisilazideHCID 47385581-benzyl-1,5,6,7-tetrahydro-4H-indazol-4-one

생성물 1

HCID 201465995-acetyl-1-benzyl-1,5,6,7-tetrahydro-4H-indazol-4one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

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온도
-78 °C

실험 절차

To a solution of 321 ml of 1.0 N lithium bis(trimethylsilyl)amide in 350 ml of anhydrous tetrahydrofuran maintained at -78° C, there was added dropwise a solution of 33 g of 1-benzyl-1,5,6,7-tetrahydro-4H-indazol-4-one in 150 ml of anhydrous tetrahydrofuran. The mixture was stirred at -78° C. for 10 minutes and then a solution of 11.4 g of acetyl chloride in 120 ml of anhydrous tetrahydrofuran was added. The reaction mixture was worked up in the same manner as described in the first paragraph of this example to give 5-acetyl-1-benzyl-1,5,6,7-tetrahydro-4H-indazol-4one as a yellow oil which crystallized on standing.

출처 및 근거

ORD 기록
ord-afb6b5bd28ab4ea1a90faca3d28848bf
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734430

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