Methyl 2-furoate → Methyl tetrahydrofuran-2-carboxylate

HRID 569925

반응식

HRID 569925 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8][CH3:9])=[O:7]>CO.[Pd]>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([O:8][CH3:9])=[O:7]

참가 물질

4

반응물 1

HCID 11902Methyl 2-furoate2회

생성물 1

HCID 169922Methyl tetrahydrofuran-2-carboxylate수율 92%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Methyl furoate (75 g, 0.595 mole) was dissolved in MeOH (150 ml), and poured into a Parr bottle. Air was replaced with argon, and then 10% Pd/C (2.5 g) was added. The atmosphere was replaced with H2 and methyl furoate was hydrogenated at 40 psi for 48 hours. The reaction was filtered through celite pad, and the pad was washed with ether. The filtrate and the wash were combined and distilled to give the title compound (71 g, 0.546 mole, 59° C./5.1 mmHg, 92%) as a colorless liquid.

후처리

  1. additionpoured into a Parr bottle
  2. filtrationThe reaction was filtered through celite pad
  3. washthe pad was washed with ether
  4. distillationdistilled

출처 및 근거

ORD 기록
ord-b6bad2c91bf244d1a8fcdf4e4b97bc17
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734424

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