Ammonium Hydroxide → HCID 13784124, 화합물

HRID 569993노트

반응식

HRID 569993 반응식
Cl[CH2:2][C:3]1[C:8]([C:9](OCC)=[O:10])=[CH:7][N:6]=[C:5]([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:16][CH2:15]2)[N:4]=1.[NH4+:27].[OH-].C([O-])(O)=O.[Na+]>C(O)C>[CH2:20]([N:17]1[CH2:16][CH2:15][N:14]([C:5]2[N:6]=[CH:7][C:8]3[C:9](=[O:10])[NH:27][CH2:2][C:3]=3[N:4]=2)[CH2:19][CH2:18]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 14923Ammonium HydroxideHCID 516892Sodium BicarbonateHCID 13769878Ethyl 4-(chloromethyl)-2-[4-(phenylmethyl)-1-piperazinyl]-5-pyrimidinecarboxylate

생성물 1

HCID 13784124HCID 13784124, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dissolved in 10 ml of ethanol was 2.25 g (6 mmol) of ethyl 4-chloromethyl-2-(4-benzylpiperazino)pyrimidine-5-carboxylate (Referential Example 41), followed by an addition of 10 ml (59 mmol) of a 30% aqueous NH4OH solution at 20° C. The resultant mixture was stirred for 12 hours. The reaction mixture was poured in a 10% aqueous NaHCO3 solution, followed by extraction with CHCl3. The solvent was then distilled off and the residue was recrystallized from toluene.

후처리

  1. extractionfollowed by extraction with CHCl3
  2. distillationThe solvent was then distilled off
  3. customthe residue was recrystallized from toluene

출처 및 근거

ORD 기록
ord-673874d9d64e45babc7ad0f4104005f3
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734418

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