Piperazine → 2-Piperazino-6,7-dimethoxyquinazoline

HRID 570011노트

반응식

HRID 570011 반응식
Cl[C:2]1[N:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([O:12][CH3:13])[CH:8]=2)[N:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(O)CC(C)C>[N:16]1([C:2]2[N:11]=[CH:10][C:9]3[C:4](=[CH:5][C:6]([O:14][CH3:15])=[C:7]([O:12][CH3:13])[CH:8]=3)[N:3]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 18181442-Chloro-6,7-dimethoxyquinazoline

생성물 1

HCID 137841852-Piperazino-6,7-dimethoxyquinazoline수율 91%

시약·촉매·용매 1

HCID 31260Isoamyl Alcohol용매

실험 절차

Refluxed for 2 hours in isoamyl alcohol (15 ml) were 0.63 g of 2-chloro-6,7-dimethoxyquinazoline (synthesized by the method described in Japanese Patent Laid-Open No. 36390/1972) and 0.72 g of anhydrous piperazine. Isoamyl alcohol was thereafter distilled off under reduced pressure, followed by extraction with 2N--NaOH and chloroform. The chloroform layer was washed with saturated saline and then dried with anhydrous magnesium sulfate. Chloroform was distilled off under reduced pressure to obtain 0.7 g of the intended product (yield: 91%).

후처리

  1. customsynthesized by the method
  2. distillationIsoamyl alcohol was thereafter distilled off under reduced pressure
  3. extractionfollowed by extraction with 2N
  4. washThe chloroform layer was washed with saturated saline
  5. dry with materialdried with anhydrous magnesium sulfate
  6. distillationChloroform was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-021aededadf048898074c8fd46bc7614
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04734418

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