6-amino-1,2-dihydro-3H-indazol-3-one → HCID 78425871, 화합물

HRID 57054

반응식

HRID 57054 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]#[N:26])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:20][CH2:21][O:22][CH3:23])[C:17]([OH:19])=O)[C:10](=[O:24])[CH:9]=2)[CH:7]=1.[NH2:27][C:28]1[CH:36]=[C:35]2[C:31]([C:32](=[O:37])[NH:33][NH:34]2)=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:25]#[N:26])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:20][CH2:21][O:22][CH3:23])[C:17]([NH:27][C:28]3[CH:36]=[C:35]4[C:31]([C:32](=[O:37])[NH:33][NH:34]4)=[CH:30][CH:29]=3)=[O:19])[C:10](=[O:24])[CH:9]=2)[CH:7]=1

참가 물질

3

반응물 2

HCID 1088016-amino-1,2-dihydro-3H-indazol-3-oneHCID 1176229442-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acid

생성물 1

HCID 78425871HCID 78425871, 화합물

실험 절차

150 mg (377 μmol) of 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acid (racemate) and 65 mg (438 μmol, 1.1 eq.) of 6-amino-1H-indazol-3(2H)-one were reacted according to General Method 1. The crude product was purified by flash chromatography (silica gel 50, dichloromethane/methanol mixtures). Yield: 105 mg (52% of theory)

후처리

  1. customThe crude product was purified by flash chromatography (silica gel 50, dichloromethane/methanol mixtures)

출처 및 근거

ORD 기록
ord-0d272ada47164648ba809b68862f9443
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434690B2

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