Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2,6-dichloro-9-cyclohexyl-9H-purine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Iodocyclohexane | HCID 12289 | — |
| 반응물 | 2,6-Dichloropurine | HCID 5324412 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 2,6-dichloro-9-cyclohexyl-9H-purine | HCID 20341610 | 41% |
반응 단계
2,6-Dichloropurine (1 mmol), powdered potassium carbonate (4 mmol) and cyclohexyliodide were vigorously stirred in 5 mL DMSO overnight. After evaporation of the solvent the product was extracted (water/diethylether) and purified by column chromatography (silicagel/1% MeOH in CHCl3). Crystallization from diethylether gave product in 41% yield, mp 116-121° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09023857B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-75f174a3bf01459fb4db87c03d30f52f |
| 출처 메모 | uspto-grants-2015_05 |