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Triethylamine → 2-Benzyl-5-(4-cyanophenyl)-7-methyl-3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

HRID 570868
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인쇄 미리보기

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HRID 570868 반응식
[N+](C1C=CC(O[C:11]([N:13]2[CH:18]([C:19]3[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=3)[C:17]([C:27]([O:29][CH3:30])=[O:28])=[C:16]([CH3:31])[N:15]=[C:14]2OC)=[O:12])=CC=1)([O-])=O.Cl.[CH2:35]([NH:42][NH2:43])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.CCN(CC)CC>CC#N>[CH3:30][O:29][C:27]([C:17]1[CH:18]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[N:26])=[CH:23][CH:24]=2)[N:13]2[C:11](=[O:12])[N:42]([CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[N:43]=[C:14]2[NH:15][C:16]=1[CH3:31])=[O:28]
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참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 14084Hydrazine, (phenylmethyl)-, hydrochloride (1:1)HCID 866782176-(4-Cyanophenyl)-2-methoxy-4-methyl-6H-pyrimidine-1,5-dicarboxylic acid 5-methyl ester 1-(4-nitrophenyl) ester

생성물 1

HCID 1363595112-Benzyl-5-(4-cyanophenyl)-7-methyl-3-oxo-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester수율 45.3%

시약·촉매·용매 1

HCID 6342
Acetonitrile
용매

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온도
0 °C

실험 절차

Intermediate 5 (250 mg, 0.55 mmol) and benzyl hydrazine hydrochloride (120 mg, 0.61 mmol) were suspended in CH3CN (10 mL) at 0° C., and Et3N (85 μl, 0.61 mmol) was added. The reaction mixture was stirred at 0° C. for 30 mins and then allowed to reach RT and stirred for a further 1 hour. The reaction mixture was filtered and the filtrate was concentrated in vacuo. The resulting residue was purified by silica gel chromatography eluting with a gradient of 0-100% to yield the title compound as a yellow solid (100 mg).

후처리

  1. customto reach RT
  2. stirringstirred for a further 1 hour
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated in vacuo
  5. customThe resulting residue was purified by silica gel chromatography
  6. washeluting with a gradient of 0-100%

출처 및 근거

ORD 기록
ord-9d53a47cd66a473a987b976aa878eadc
출처 데이터셋
uspto-grants-2015_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09023855B2

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