Triethylamine → HCID 178456702, 화합물

HRID 570952노트

반응식

HRID 570952 반응식
[CH3:1][O:2][C:3](=[O:6])[CH2:4][NH2:5].C(N(CC)CC)C.[IH:14].[O:15]=[C:16]1[N:21]([CH2:22][C:23]#[CH:24])[N:20]=[N:19][C:18]2=[C:25]([C:28](SC)=[NH:29])[N:26]=[CH:27][N:17]12>CC#N>[IH:14].[CH3:1][O:2][C:3](=[O:6])[CH2:4][NH:5][C:28]([C:25]1[N:26]=[CH:27][N:17]2[C:16](=[O:15])[N:21]([CH2:22][C:23]#[CH:24])[N:20]=[N:19][C:18]=12)=[NH:29]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 69221Glycine methyl esterHCID 86663789Methyl 4-oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide

생성물 1

HCID 178456702HCID 178456702, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Glycine methyl ester (0.14 mmol) was suspended in dry MeCN (1 mL). Triethylamine (0.14 mmol) was added and the solution stirred for 10 minutes. Methyl 4-oxo-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbimidothioate hydroiodide (0.13 mmol) was then added and the reaction stirred at room temperature for 2 hours. The resulting precipitate was then filtered and washed with MeCN and ether. δH (DMSO-d6) 9.70 (2H, bs), 9.22 (1H, s), 5.76 (1H, s), 5.24 (2H, d, J=2.4), 4.45 (2H, s), 3.74 (3H, s), 3.60 (1H, t, J=2.4).

후처리

  1. stirringthe reaction stirred at room temperature for 2 hours
  2. filtrationThe resulting precipitate was then filtered
  3. washwashed with MeCN and ether

출처 및 근거

ORD 기록
ord-78cea099be5a414ea56d72ae158e9a64
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024018B2

반응 노트

불러오는 중…