Potassium Carbonate → HCID 86681617, 화합물

HRID 571201노트

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HRID 571201 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:13])[C:8](=[O:12])[NH:9]2)=[CH:5][CH:4]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>C(#N)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:13])[C:8](=[O:12])[N:9]2[CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 103749726-Methoxyisatin

생성물 1

HCID 86681617HCID 86681617, 화합물수율 96%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 6-methoxyindoline-2,3-dione (350 mg, 1.976 mmol) in acetonitrile (10 ml), K2CO3 (328 mg, 2.371 mmol) and tert-butyl 2-bromoacetate (350 μl, 2.371 mmol) were added, and the mixture was reacted at room temperature overnight. The insoluble inorganic salts were filtered off and the solvent was evaporated obtaining the crude title compound (550 mg, 1.888 mmol, 96% yield). MS/ESI+ 292.1 [MH]+. The crude was used in the next step without further purification.

후처리

  1. customthe mixture was reacted at room temperature overnight
  2. filtrationThe insoluble inorganic salts were filtered off
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-d8b5d0ab53c44c08b68b844e367fb313
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09024027B2

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