참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Picolinic acid | HCID 1018 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2,3-Dimethyliodobenzene | HCID 141645 | — |
| 반응물 | 2-(4-Hydroxy-phenyl)-morpholine-4-carboxylic acid tert-butyl ester | HCID 66654239 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | HCID 66653709 | HCID 66653709 | — |
반응 단계
To a degassed solution of 2-(4-hydroxy-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (10.23 g; 36.6 mmol), and 1-iodo-2,3-dimethyl-benzene (10.62 g; 45.8 mmol) in DMSO (50 mL), was added picolinic acid (0.90 g; 7.3 mmol), CuI (0.70 g; 3.7 mmol) and K3PO4 (15.55 g; 73.3 mmol). The resulting mixture was heated overnight, at 90° C. After cooling to RT, brine was added and the mixture extracted with CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by column chromatography (SiO2, CH2Cl2) to afford 2-[4-(2,3-dimethyl-phenoxy)-phenyl]-morpholine-4-carboxylic acid tert-butyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09029371B2 |
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| 출처 데이터셋 | uspto-grants-2015_05 |
|---|
| ORD ID | ord-d646cfaf2d234009a22bae0a8e0e0f5d |
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| 출처 메모 | uspto-grants-2015_05 |
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