4-Bromo-2-chlorobenzoyl chloride → (RS)-2-(4-Amino-2-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[C:16](F)[CH:15]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].BrC1C=CC(C([Cl:29])=O)=C(Cl)C=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][C:15]=2[Cl:29])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 155922074-Bromo-2-chlorobenzoyl chloride

HCID 68325450Tert-butyl 2-(4-amino-3-fluorophenyl)morpholine-4-carboxylate

생성물 1

HCID 68356525(RS)-2-(4-Amino-2-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester

실험 절차

In analogy to (RS)-2-(4-Amino-3-fluoro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester (Example 1, steps a-g) using 4-bromo-2-chlorobenzoyl chloride (CAS 21900-55-0) instead of 4-bromo-3-fluorobenzoyl chloride.

출처 및 근거

ORD 기록: ord-107d212c33244558a8da05d6ef47cad7
출처 데이터셋: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09029370B2

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