Isatin → 5-Chloro-3-[2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one

반응식

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6](=[O:12])[C:5]2=[O:13].N1C2C(=CC=CC=2)C(=O)C1=O.[F:25][CH:26]([F:36])[CH2:27][O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1I>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6](=[O:12])[C:5]2([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[O:28][CH2:27][CH:26]([F:25])[F:36])[OH:13]

참가 물질

반응물 3

HCID 7054Isatin

HCID 167818735-Chloro-6-fluoroindoline-2,3-dione

HCID 614001452,2-Difluoroethoxyiodobenzene

생성물 1

HCID 867254505-Chloro-3-[2-(2,2-difluoroethoxy)phenyl]-6-fluoro-3-hydroxy-1,3-dihydroindol-2-one

실험 절차

The title compound was prepared in analogy to example a.1 using 5-chloro-6-fluoroisatin as isatin II and 2,2-difluoroethoxyiodobenzene (to form the Grignard reagent).

출처 및 근거

ORD 기록: ord-9d6951232918402db41f989e083e6721
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09434713B2

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