Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → Phenyl isoquinolin-4-ylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Phenyl chloroformate | HCID 15891 | — |
| 반응물 | 4-Aminoisoquinoline | HCID 90237 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Phenyl isoquinolin-4-ylcarbamate | HCID 58442686 | 59% |
반응 단계
Isoquinolin-4-amine (296 mg, 2.05 mmol) was dissolved in acetonitrile. To the reaction mixture was added pyridine (0.20 mL, 2.46 mmol) and phenyl chloroformate (0.27 mL, 2.15 mmol), respectively and stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was concentrated under reduced pressure. The crude was purified by column chromatography to give phenyl isoquinolin-4-ylcarbamate (318 mg, 59%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09029378B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-115e81effb614df49d9fdd22c812890e |
| 출처 메모 | uspto-grants-2015_05 |