[8-Chloro-2-(pyridin-3-yl)quinolin-3-yl]methanol → 8-Chloro-2-(pyridin-3-yl)quinoline-3-carbaldehyde

HRID 572123노트

반응식

HRID 572123 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[C:8]([CH2:18][OH:19])=[CH:7]2>ClC1C=CC=CC=1.O=[Mn]=O>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[C:8]([CH:18]=[O:19])=[CH:7]2

참가 물질

4

반응물 1

HCID 66691162[8-Chloro-2-(pyridin-3-yl)quinolin-3-yl]methanol

생성물 1

HCID 867011658-Chloro-2-(pyridin-3-yl)quinoline-3-carbaldehyde수율 86.3%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 7964Chlorobenzene용매

반응 조건

온도
70 °C

실험 절차

A mixture of [8-chloro-2-(pyridin-3-yl)quinolin-3-yl]methanol (0.6 g, 2.2 mmol) and MnO2 (1.0 g) in chlorobenzene (30 mL) was heated at 70° C. overnight, filtered through a celite plug, concentrated in vacuo and washed with DCM to give the title compound (510 mg, 86%) as a white solid.

후처리

  1. filtrationfiltered through a celite plug
  2. concentrationconcentrated in vacuo
  3. washwashed with DCM

출처 및 근거

ORD 기록
ord-bd499a79d24743db8d495e4983418023
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029392B2

반응 노트

불러오는 중…