Chloroacetyl chloride → N-benzyl-2-chloro-N-methylacetamide

HRID 57217

반응식

HRID 57217 반응식
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Cl:10][CH2:11][C:12](Cl)=[O:13]>CCOC(C)=O.C([O-])(O)=O.[Na+]>[CH2:3]([N:2]([CH3:1])[C:12](=[O:13])[CH2:11][Cl:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 6577Chloroacetyl chlorideHCID 7669N-Methylbenzylamine

생성물 1

HCID 4639192N-benzyl-2-chloro-N-methylacetamide수율 63.2%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 516892Sodium Bicarbonate용매

실험 절차

To a vigorously stirred suspension of N-methylbenzylamine (0.260 mL, 2 mmol) in EtOAc (3 mL) and 3 mL of saturated NaHCO3 solution was added chloroacetyl chloride (0.160 mL, 2 mmol). Effervescence was observed. Once gas production had ceased, the reaction mixture was diluted with hexanes (10 mL). The phases were separated and the organic phase was washed with brine (5 mL), dried and concentrated to yield ˜0.250 g of the title compound as an oil. The crude material was used in the subsequent step without further purification.

후처리

  1. customThe phases were separated
  2. washthe organic phase was washed with brine (5 mL)
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5566117e5a23432883496a6c102eaef6
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434718B2

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