Acetic Acid → 4-Amino-2-fluorobenzoic acid

HRID 57226

반응식

HRID 57226 반응식
[F:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(O)(=O)C>[Pd].CO>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([F:1])[CH:10]=1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

생성물 1

HCID 3026804-Amino-2-fluorobenzoic acid수율 102.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 2-fluoro-4-nitrobenzoic acid (1.0 g, 5.4 mmol) in 20 mL of a mixture of acetic acid and methanol (1:1), was added a catalytic amount of palladium on charcoal (25 mg). The reaction was stirred under an atmosphere of hydrogen gas at room temperature overnight. The mixture was then filtered through celite and the solvent was removed by evaporation to yield 0.86 g (100%) of the title compound as a cream coloured solid.

후처리

  1. filtrationThe mixture was then filtered through celite
  2. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-2272ef503ec54d5b831c7c1d91da81fd
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434720B2

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