Trifluoroacetic acid → 4-Cyano-3-(2,4-dichlorophenyl)-N-hydroxy-5-morpholin-4-yl-thiophene-2-carboxamide

HRID 572630노트

반응식

HRID 572630 반응식
[C:1]([C:3]1[C:4]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[Cl:31])=[C:5]([C:14]([NH:16][O:17]C2CCCCO2)=[O:15])[S:6][C:7]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:3]1[C:4]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[Cl:31])=[C:5]([C:14]([NH:16][OH:17])=[O:15])[S:6][C:7]=1[N:8]1[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1)#[N:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 866375484-Cyano-3-(2,4-dichlorophenyl)-5-morpholin-4-yl-N-(tetrahydro-2H-pyran-2-yloxy)thiophene-2-carboxamide

생성물 1

HCID 441551214-Cyano-3-(2,4-dichlorophenyl)-N-hydroxy-5-morpholin-4-yl-thiophene-2-carboxamide수율 75.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Cyano-3-(2,4-dichlorophenyl)-5-morpholin-4-yl-N-(tetrahydro-2H-pyran-2-yloxy)thiophene-2-carboxamide (0.050 g, 0.10 mmol) was dissolved in DCM (3 mL) and TFA (0.24 mL, 3.11 mmol) was added. The solution was stirred at room temperature overnight. Solvent was evaporated and the residue was purified by column chromatography (silica gel, elution with DCM to 10% MeOH in DCM over 20 minutes) to give the title compound 24 (0.030 g, 67%). LCMS: (FA) ES+ 398.

후처리

  1. customSolvent was evaporated
  2. customthe residue was purified by column chromatography (silica gel, elution with DCM to 10% MeOH in DCM over 20 minutes)

출처 및 근거

ORD 기록
ord-784169b2c59e459d81516dd34ad282bc
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029411B2

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