Methylamine → HCID 32890706, 화합물

HRID 572692

반응식

HRID 572692 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:13])[N:6]([CH2:8][C:9](OC)=[O:10])[CH:7]=1.[CH3:14][NH2:15]>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:13])[N:6]([CH2:8][C:9]([NH:15][CH3:14])=[O:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 28834262methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate

생성물 1

HCID 32890706HCID 32890706, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of methyl 2-(5-bromo-2-oxopyridin-1(2H)-yl)acetate (0.5 g, 1.92 mmol, WO 2009134400) in 2M solution of Methyl amine in THF (5 mL) was stirred at RT for 16 h. The separated solid is collected by filtration and dried under vacuum to afford 2-(5-bromo-2-oxopyridin-1(2H)-yl)-N-methylacetamide as off-white solid, 0.35 g (74%), 1H NMR (400 MHz, DMSO): 8.09 (1H, d, J=4.4 Hz), 7.93 (1H, d, J=2.4 Hz), 7.54 (1H, dd, J=3.0, 9.8 Hz), 6.36 (1H, d, J=9.8 Hz), 4.47 (2H, s), 2.61 (3H, d, J=4.9 Hz). ES-MS: 247.1 (M+2H).

후처리

  1. filtrationThe separated solid is collected by filtration
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-dd1d11926b3c4470b238918959edb734
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029409B2

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