Methylamine → HCID 178483385, 화합물

HRID 57282노트

반응식

HRID 57282 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 178509116HCID 178509116, 화합물

생성물 1

HCID 178483385HCID 178483385, 화합물수율 32%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

후처리

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

출처 및 근거

ORD 기록
ord-a7b93501c10844e5a3d77d0eafb4e72b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434720B2

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