m-Chloroperbenzoic acid → Methyl thieno[3,4-b]thiophene-2-carboxylate

HRID 572904노트

반응식

HRID 572904 반응식
[CH3:1][O:2][C:3]([C:5]1[S:9][C:8]2[CH2:10][S:11][CH2:12][C:7]=2[CH:6]=1)=[O:4].C1C=C(Cl)C=C(C(OO)=O)C=1>C(OCC)(=O)C.C(=O)=O>[S:9]1[C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]2=[CH:12][S:11][CH:10]=[C:8]12

참가 물질

5

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 3441857Methyl 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylate

생성물 1

HCID 19007653Methyl thieno[3,4-b]thiophene-2-carboxylate

시약·촉매·용매 2

HCID 280Carbon Dioxide용매HCID 8857Ethyl Acetate용매2회

실험 절차

A solution of 2.0 g (10 mmol) (3) in 30 mL ethyl acetate was stirred and cooled down in dry ice bath. MCPBA (1.75 g, 10 mmol) in 30 mL ethyl acetate was added dropwise to the reaction solution. After the addition, the mixture was kept stirring for overnight. Then the solvent was removed by evaporation and the residue contained a crude product of (4) and 3-chlorobenzoic acid.

후처리

  1. additionAfter the addition
  2. customThen the solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-d05f430b1b2c4181be7bdca80667deae
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029499B2

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