Triethylamine → Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

HRID 572923노트

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HRID 572923 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>ClCCl>[CH3:21][S:22]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:7]=1)(=[O:24])=[O:23]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 225219p-Aminophenylacetic acid ethyl ester

생성물 1

HCID 10038092Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The solution of ethyl 2-(4-aminophenyl)acetate (500 mg, 2.79 mmol) and triethylamine (0.58 mL, 4.18 mmol) in dichloromethane (30 mL) was added methanesulfonyl chloride (0.24 mL, 3.07 mmol) dropwise at room temperature and stirred overnight. The mixture was washed with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to give desired compound. LC-MS: m/z (M+H)=258.3

후처리

  1. washThe mixture was washed with brine
  2. dry with materialdried over sodium sulfate
  3. customevaporated under reduced pressure
  4. customThe residue was purified by a standard method

출처 및 근거

ORD 기록
ord-fb2d1e9b58c144f7bd732f22ef461a7e
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029531B2

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