Methyl (5-nitropyridin-2-yl)acetate → Methyl 2-(5-aminopyridin-2-yl)acetate
반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1참가 물질
4
실험 절차
The solution of methyl 2-(5-nitropyridin-2-yl)acetate (500 mg, 2.5 mmol) and Pd/C (50 mg) in methanol (20 mL) was stirred under H2 at room temperature for 3 h. Then, the reaction mixture was filtered and evaporated under reduced pressure to get desired product for the next step without further purification.
후처리
- filtrationThen, the reaction mixture was filtered
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-04132ee18ea14776832296a6aeed03fb
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09029531B2
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