Tetrabutylammonium Fluoride → 3-Ethynyl-imidazo[1,2-A]pyrazine

HRID 572959노트

반응식

HRID 572959 반응식
C[Si]([C:5]#[C:6][C:7]1[N:11]2[CH:12]=[CH:13][N:14]=[CH:15][C:10]2=[N:9][CH:8]=1)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[C:6]([C:7]1[N:11]2[CH:12]=[CH:13][N:14]=[CH:15][C:10]2=[N:9][CH:8]=1)#[CH:5]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 667356023-((Trimethylsilyl)ethynyl)imidazo[1,2-a]pyrazine

생성물 1

HCID 722072723-Ethynyl-imidazo[1,2-A]pyrazine수율 77.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-((Trimethylsilyl)ethynyl)imidazo[1,2-a]pyrazine (0.15 g, 0.7 mmol) in 3.5 mL of THF was added 1.05 mL (1.05 mmol) of tetrabutylammonium fluoride (1.0M in THF) at ambient temperature. The solution was stirred for 15 min, concentrated, and the crude product purified by silica gel flash chromatography (eluted with 50% EtOAc/hexanes) to provide 0.078 g of product.

후처리

  1. concentrationconcentrated
  2. customthe crude product purified by silica gel flash chromatography (eluted with 50% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-8e5673f5464c4b4181ed91be38e6c7d5
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029533B2

반응 노트

불러오는 중…