Tetrabutylammonium Fluoride → 3-Ethynylimidazo[1,2-b]pyridazine

HRID 572985노트

반응식

HRID 572985 반응식
C[Si]([C:5]#[C:6][C:7]1[N:11]2[N:12]=[CH:13][CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[C:6]([C:7]1[N:11]2[N:12]=[CH:13][CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1)#[CH:5]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 667355693-((Trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazine

생성물 1

HCID 468387603-Ethynylimidazo[1,2-b]pyridazine수율 94.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-((trimethylsilyl)ethynyl) imidazo[1,2-b]pyridazine (28.46 g, 0.132 mol) in 200 mL of THF was added 145 mL (0.145 mol) of tetrabutylammonium fluoride (1.0M in THF) at ambient temperature. The solution was stirred for 15 min, concentrated, and the crude product purified by silica gel flash chromatography (eluted with 0-5% MeOH/DCM) to provide 17.84 g of product.

후처리

  1. concentrationconcentrated
  2. customthe crude product purified by silica gel flash chromatography (eluted with 0-5% MeOH/DCM)

출처 및 근거

ORD 기록
ord-7691fb09671b4b11951e1fb3f4bc8217
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029533B2

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