Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → ethyl 4-fluoro-2-(2-methyl-1H-indol-5-yloxy)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 2-methyl-1H-indol-5-ol | HCID 83336 | — |
| 반응물 | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| 용매 | Diglyme | HCID 8150 | — |
| 생성물 | ethyl 4-fluoro-2-(2-methyl-1H-indol-5-yloxy)benzoate | HCID 67227223 | — |
반응 단계
Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 2-methyl-5-indolol (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The mixture was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and with brine, and dried. The solution was then concentrated. The concentrate was chromatographed on silica gel with 10% ethyl acetate/hexanes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09029404B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-1ee6f62c08ad4d0db339638b3a8d1d3c |
| 출처 메모 | uspto-grants-2015_05 |