Trifluoroacetic acid → HCID 67227744, 화합물

HRID 573074노트

반응식

HRID 573074 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH:14]([N:16]2[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]2)[CH3:15])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH:14]([N:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[CH3:15])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67225632HCID 67225632, 화합물

생성물 1

HCID 67227744HCID 67227744, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution of EXAMPLE 110B (650 mg) in dichloromethane (6 mL) at 0° C. was added trifluoroacetic acid (6 mL). The mixture was stirred at 0° C. for 50 minutes and concentrated. The concentrate was dissolved in dichloromethane, washed with aqueous NaHCO3 and dried over Na2SO4, filtered and concentrated.

후처리

  1. concentrationconcentrated
  2. dissolutionThe concentrate was dissolved in dichloromethane
  3. washwashed with aqueous NaHCO3
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aa9f0c83a2b549de97847d239d450ee0
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029404B2

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