참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 4-Amino-2-chlorophenol | HCID 77578 | — |
| 반응물 | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| 용매 | Diglyme | HCID 8150 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl 2-(4-amino-2-chlorophenoxy)-4-fluorobenzoate | HCID 67228057 | — |
반응 단계
To a solution of ethyl 2,4-difluorobenzoate (6.48 g) and 4-amino-2-chlorophenol (5.0 g) in diglyme (40 mL) was added K3PO4 (7.39 g). The mixture was stirred at 110° C. overnight. The mixture was diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. The mixture was filtered, and the solvent was evaporated and the residue was loaded on a column and eluted with 10% ethyl acetate in hexane to give the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09029404B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_05 |
|---|
| ORD ID | ord-788b9a1f586a424c98e346ebf676b9f6 |
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| 출처 메모 | uspto-grants-2015_05 |
|---|
