Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 573120노트

반응식

HRID 573120 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

생성물 1

HCID 31128494-Morpholinobut-2-YN-1-OL

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
85 °C

실험 절차

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-84a783c69d3242d8af76c32df19a7a26
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029404B2

반응 노트

불러오는 중…