Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyano-borohydride → 4-((4-Fluoro-1-(oxetan-3-yl)piperidin-4-yl)methoxy)-3-nitrobenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyano-borohydride | HCID 498716 | — |
| 반응물 | 3-Oxetanone | HCID 15024254 | — |
| 반응물 | 4((4-Fluoropiperidin-4-yl)methoxy)-3-nitrobenzenesulfonamide | HCID 67126502 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-((4-Fluoro-1-(oxetan-3-yl)piperidin-4-yl)methoxy)-3-nitrobenzenesulfonamide | HCID 67127155 | — |
반응 단계
To a solution of EXAMPLE 341C (72 mg) in tetrahydrofuran (1.5 mL) and acetic acid (0.5 mL) was added oxetan-3-one (14 mg) and MP-cyanoborohydride (2.38 mmol/g, 162 mg). The mixture was stirred at room temperature overnight. The reaction was then filtered and the filtrate was concentrated under vacuum. The residue was slurried in ether and the product was collected by filtration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09029404B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-e7b29ce207654796a5a686b34844e679 |
| 출처 메모 | uspto-grants-2015_05 |