참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trichloroisocyanuric Acid | HCID 6909 | — |
| 반응물 | 4-Fluoro-2-nitrotoluene | HCID 67965 | — |
| 반응물 | Acetic acid sulfuric acid | HCID 23350293 | — |
| 생성물 | 4-Methylcatechol | HCID 9958 | 33.1% |
반응 단계
TCCA (16.7 g, 72 mmol) was added to a solution of 4-fluoro-1-methyl-2-nitrobenzene (12.4 g, 80 mmol) in CH3CO2H/H2SO4 (80 mL/80 mL). The mixture was heated to 70° C. and stirred overnight. After cooling to room temperature, the reaction mixture was poured into ice water (1000 mL) and extracted with DCM (2×200 mL). The combined organic phase was washed with brine and concentrated in vacuo. The residue was purified by column chromatography (PE: EA=50:1) to give compound 1 (5.0 g, 33.1%) as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434724B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-6a5d8e0b4f2f48f6baff74346c1a6d6d |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
