Water → 3-bromo-1-isopropyl-1H-pyrazolo[4,3-b]pyridine

HRID 573289노트

반응식

HRID 573289 반응식
[Br:1][C:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[NH:4][N:3]=1.I[CH:12]([CH3:14])[CH3:13].C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[Br:1][C:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]([CH:12]([CH3:14])[CH3:13])[N:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 178419484HCID 178419484, 화합물

생성물 1

HCID 667280773-bromo-1-isopropyl-1H-pyrazolo[4,3-b]pyridine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 3-bromo-1H-pyrazolo[4,3-b]pyridine (200 mg) in DMF (10 mL) were added 2-iodopropane (0.20 mL) and K2CO3 (168 mg) at room temperature. After stirring overnight, the reaction mixture was poured into water and extracted with AcOEt. The extract was washed with water and brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (AcOEt/hexane) to give the title compound (147 mg).

후처리

  1. extractionextracted with AcOEt
  2. washThe extract was washed with water and brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by basic silica gel column chromatography (AcOEt/hexane)

출처 및 근거

ORD 기록
ord-aaa3de8565e3451387055b3d63cba6ea
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

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