Water → HCID 66727774, 화합물

HRID 573335

반응식

HRID 573335 반응식
[CH3:1][S:2][C:3]1[NH:11][C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=1.Br[CH2:13][CH2:14][O:15][CH3:16].O>CN(C=O)C>[CH3:16][O:15][CH2:14][CH2:13][N:11]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[S:2][CH3:1]

참가 물질

5

반응물 3

HCID 962WaterHCID 809722-Bromoethyl methyl etherHCID 178503348HCID 178503348, 화합물

생성물 1

HCID 66727774HCID 66727774, 화합물수율 37%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 2-(methylthio)-3H-imidazo[4,5-b]pyridine (400 mg) and 1-bromo-2-methoxyethane (370 mg) in DMF (7 mL) was stirred at 80° C. for 3 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (200 mg).

후처리

  1. extractionextracted with AcOEt
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)

출처 및 근거

ORD 기록
ord-121940b42852495aba1fb74a162ccf8a
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

연결된 노트

불러오는 중…