Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → (2S, 5R)-6-sulfooxy-2-(aminomethyl)-7-oxo-1,6-diaza-bicyclo [3.2.1]octane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 6-Sulfooxy-2-(amino methyl)-7-oxo-1,6-diazabicyclo[3.2.1]octane | HCID 118011118 | — |
| 용매 | Propan-2-ol--water (1/1) | HCID 21889133 | — |
| 생성물 | (2S, 5R)-6-sulfooxy-2-(aminomethyl)-7-oxo-1,6-diaza-bicyclo [3.2.1]octane | HCID 91669185 | — |
반응 단계
The compound of Formula (IX) was reacted with trifluoroacetic acid in a suitable solvent such as dichloromethane to provide trifluoroacetic acid and sodium salt of 6-sulfooxy-2-(amino methyl)-7-oxo-1,6-diazabicyclo[3.2.1]octane (X). This trifluoroacetic acid and sodium salt (X) was further treated with water isopropyl alcohol mixture to obtain zwitterion form, (2S, 5R)-6-sulfooxy-2-(aminomethyl)-7-oxo-1,6-diaza-bicyclo[3.2.1]octane (XI).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434728B1 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-d88982eb8b204e5e946a4513e5966aca |
| 출처 메모 | uspto-grants-2016_09 |