Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate → Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate

HRID 573343노트

반응식

HRID 573343 반응식
[CH2:1]([N:3]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([N+:12]([O-])=O)[CH:5]=[N:4]1)[CH3:2]>CO.[Pd]>[NH2:12][C:6]1[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

참가 물질

4

반응물 1

HCID 54775328Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

생성물 1

HCID 54775640Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate수율 96.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate (2.2 g) and 10% Pd—C (0.60 g) in MeOH (30 mL) was hydrogenated under balloon pressure at room temperature overnight. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (1.8 g).

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0bafab80cc2d4d5489845deb549d1470
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

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