7-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine → HCID 66727973, 화합물

HRID 573346노트

반응식

HRID 573346 반응식
Cl[C:2]1[C:3]2[N:10]([CH2:11][CH3:12])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1>CCOC(C)=O.[Pd]>[CH2:11]([N:10]1[C:3]2[CH:2]=[N:7][CH:6]=[N:5][C:4]=2[CH:8]=[N:9]1)[CH3:12]

참가 물질

4

반응물 1

HCID 714458087-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine

생성물 1

HCID 66727973HCID 66727973, 화합물수율 93.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 7-chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine (105 mg), TEA (0.088 mL) and 10% Pd—C (30 mg) in AcOEt (5 mL) was hydrogenated under balloon pressure at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (80 mg).

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-82466f85a4994758adcb1ded58cd0c9f
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

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