Water → HCID 66727811, 화합물

HRID 573356

반응식

HRID 573356 반응식
[CH3:1][S:2][C:3]1[NH:11][C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=1.FC(F)(F)S(O[CH2:18][CH:19]([F:21])[F:20])(=O)=O.O>CN(C=O)C>[F:20][CH:19]([F:21])[CH2:18][N:11]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[S:2][CH3:1]

참가 물질

5

반응물 3

HCID 962WaterHCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 178503348HCID 178503348, 화합물

생성물 1

HCID 66727811HCID 66727811, 화합물수율 48%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine (600 mg) and 2,2-difluoroethyl trifluoromethanesulfonate (816 mg) in DMF (7 mL) was stirred at 80° C. for 3 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure to give the title compound (400 mg).

후처리

  1. extractionextracted with AcOEt
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2d9016d9496f45a1ab6f94d4a0165361
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029536B2

연결된 노트

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