Diethyl methyl(4-nitrophenyl)propanedioate → HCID 12370795, 화합물

HRID 573778노트

반응식

HRID 573778 반응식
[CH3:1][C:2]([C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=1)([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4]>CO.[Pd]>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([C:2]([CH3:1])([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:14][CH:15]=1

참가 물질

4

반응물 1

HCID 12380744Diethyl methyl(4-nitrophenyl)propanedioate

생성물 1

HCID 12370795HCID 12370795, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 4.98 g Diethyl 2-methyl-2-(4-nitrophenyl)malonate in 70 ml methanol are added 896 mg of 10% palladium on charcoal. The mixture is hydrogenated at 2 bar for 3 hours. After filtration the solvent is evaporated in vacuo and the residue is chromatographed on silica gel (cyclohexane/ethylacetate 90:10 to 50:50).

후처리

  1. filtrationAfter filtration the solvent
  2. customis evaporated in vacuo
  3. customthe residue is chromatographed on silica gel (cyclohexane/ethylacetate 90:10 to 50:50)

출처 및 근거

ORD 기록
ord-cbaa9f64a1554666b60f7b93d1ca5659
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029544B2

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