Isoquinoline, 1-chloro- → N-(3-Bromobenzoyl)-N-(1-isoquinolyl)hydrazine

HRID 574035

반응식

HRID 574035 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16]([NH:18][NH2:19])=[O:17]>C1(C)C=CC(C)=CC=1>[Br:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16]([N:18]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1)[NH2:19])=[O:17]

참가 물질

4

반응물 2

HCID 140539Isoquinoline, 1-chloro-HCID 520941m-Bromobenzohydrazide

생성물 1

HCID 66709633N-(3-Bromobenzoyl)-N-(1-isoquinolyl)hydrazine수율 90.6%

시약·촉매·용매 1

HCID 7809P-Xylene용매

반응 조건

온도
150 °C

실험 절차

To a 200-mL three-neck flask were added 3.3 g (20 mmol) of 1-chloroisoquinoline, 4.3 g (20 mmol) of 3-bromobenzoylhydrazine, and 80 mL of para-xylene. This mixture was refluxed at 150° C. for 14 hours under a nitrogen stream. After a predetermined time elapsed, this mixture was cooled to room temperature, and the precipitated solid was collected by suction filtration. The obtained solid was washed with toluene, a saturated aqueous solution of sodium hydrogen carbonate, and water. This solid was dried, so that the substance which was the object of the synthesis was obtained as 6.2 g of a pale yellow powder in 90% yield.

후처리

  1. temperaturethis mixture was cooled to room temperature
  2. filtrationthe precipitated solid was collected by suction filtration
  3. washThe obtained solid was washed with toluene
  4. customThis solid was dried, so that the substance which

출처 및 근거

ORD 기록
ord-a111e756426347d48c5a10da0b2ef81a
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034486B2

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