Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl 1-({[(tert-butoxycarbonyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate | HCID 66801809 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride | HCID 89780476 | — |
반응 단계
262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09034855B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-63ef24af7ed74888b706354e023f6057 |
| 출처 메모 | uspto-grants-2015_05 |