참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 6-Chloropyridazin-3-ol | HCID 252828 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-Chloro-2-methyl-2,3-dihydropyridazin-3-one | HCID 2783607 | 749.4% |
반응 단계
To a solution of 6-chloropyridazin-3(2H)-one (780 mg, 6 mmol) in CH3CN (40 mL) was added Cs2CO3 (3.9 g, 12 mmol) and CH3I (1 mL, 12 mmol) and the reaction mixture was stirred at 70° C. overnight. Solid was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/EA=3/1) to afford the title compound as orange oil (6.5 g, 75%). [LCMS: Rt=1.43 min, m/z 145.1 (M+H)+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09034874B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_05 |
|---|
| ORD ID | ord-4cde32e579f84b50bd9c9ae9491f3fb4 |
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| 출처 메모 | uspto-grants-2015_05 |
|---|
