참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidin-4-ol | HCID 79341 | — |
| 반응물 | 6-Chloro-2-methyl-2,3-dihydropyridazin-3-one | HCID 2783607 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diisopropylethylamine | HCID 81531 | — |
| 생성물 | 6-(4-hydroxypiperidin-1-yl)-2-methylpyridazin-3(2H)-one | HCID 86721994 | 83% |
반응 단계
To a slurry of 6-chloro-2-methylpyridazin-3(2H)-one (1 g, 6.94 mmol) in DIPEA (20 mL) was added piperidin-4-ol (0.84 g, 8.33 mmol) and the reaction mixture was stirred at 120° C. overnight. The resulting mixture was diluted with water (30 mL) and extracted with DCM (3×30 mL) to remove impurities. The aqueous phase was concentrated to dryness to afford the title compound as a yellow solid (1.2 g, 83%). [LCMS: Rt=1.07 min, m/z 210.1 (M+H)]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09034874B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_05 |
|---|
| ORD ID | ord-447dff96b2014eeb82a2992dbfbd8559 |
|---|
| 출처 메모 | uspto-grants-2015_05 |
|---|
