Benzyl Bromide → 2-Benzyloxy-5-bromopyridine

HRID 574175노트

반응식

HRID 574175 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[CH2:10]([O:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 7498Benzyl BromideHCID 5995285-Bromo-2-hydroxypyridine

생성물 1

HCID 111081912-Benzyloxy-5-bromopyridine수율 95%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

To a solution of 5-bromopyridin-2(1H)-one (1.28 g, 7.36 mmol) and Ag2CO3 (3 g, 11.04 mmol) in toluene (50 mL) was added (bromomethyl)benzene (1.25 g, 7.36 mmol) dropwise and the reaction mixture was stirred at 100° C. over night. The reaction mixture was filtered through a short pad of silica gel and washed with DCM. The filtrate was concentrated to yield the title compound as light yellow oil (1.8 g, 95%).

후처리

  1. filtrationThe reaction mixture was filtered through a short pad of silica gel
  2. washwashed with DCM
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9665073dbe354264a876e074aa0deb34
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034874B2

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