Water → 3-(2-Carboxypyridin-6-yl)-6-(pyridin-2-yl)-pyridazine

HRID 574190노트

반응식

HRID 574190 반응식
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:9]=[N:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:12][CH:13]=2)[CH:5]=[CH:4][CH:3]=1.[Se](=O)=[O:21].ClC1C=CC=CC=1Cl.[OH2:31]>>[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([C:8]2[N:9]=[N:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:12][CH:13]=2)[N:7]=1)([OH:21])=[O:31]

참가 물질

5

반응물 4

HCID 962WaterHCID 72391,2-DichlorobenzeneHCID 24007Selenium DioxideHCID 64179693-(6-Methylpyridin-2-yl)-6-(pyridin-2-yl)pyridazine

생성물 1

HCID 64179713-(2-Carboxypyridin-6-yl)-6-(pyridin-2-yl)-pyridazine수율 74%

반응 조건

온도
150 °C

실험 절차

400 mg (2.42 mmol) of pyridazine 44, 177 mg (1.60 mmol) of selenium dioxide and 7 ml of o-dichlorobenzene are introduced into a 100 ml round-bottomed flask equipped with a condenser. The mixture is heated at 150° C. for 4 hours, and then cooled to ambient temperature. An excess of water is added to the precipitate formed, which is filtered off and washed with water. The solid obtained is dried, so as to give the acid 45 with a yield of 74%.

후처리

  1. customequipped with a condenser
  2. temperaturecooled to ambient temperature
  3. customformed
  4. filtrationwhich is filtered off
  5. washwashed with water
  6. customThe solid obtained
  7. customis dried

출처 및 근거

ORD 기록
ord-862c866f606343ffa9b1bf435279761d
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034873B2

반응 노트

불러오는 중…